T1
Tier 1 — Holy Trinity
Randomized + double-blind + split-face (or equivalent controlled design). The highest quality bar. These studies form the primary evidence base for all efficacy claims.
METHODOLOGY
Every study is scored against a clear framework. No ambiguity, no hidden criteria. Here's exactly how it works.
Randomized + double-blind + split-face (or equivalent controlled design). The highest quality bar. These studies form the primary evidence base for all efficacy claims.
Has two of three Holy Trinity criteria. Acceptable for primary claims, but the missing criterion is always labeled explicitly.
Single-blind, open-label, or non-randomized but with objective endpoints. Used to support or contextualize higher-tier findings — never as sole evidence for strong claims.
In-vitro, animal model, mechanistic, or very small sample. Used only for hypothesis generation. Always labeled explicitly when cited.
"Studies show..."
"Evidence demonstrates..."
"Evidence suggests..."
"Research indicates..."
"Limited evidence suggests..."
"Preliminary findings..."
"Early research suggests..."
"In-vitro data indicates..."